IgG4-related disease… almost completely unknown 10 years ago.
"It is a perfect disease for rheumatologists to take care of." – Dr. John Stone #ACR18 @RheumNow— Brittany A (@MissbeeMD) October 24, 2018
IgG4-RD histopathology consistent across organs: lymphoplasmacytic infiltrate, obliterative phlebitis, storiform fibrosis. #ACR18 @RheumNow
— Brittany A (@MissbeeMD) October 24, 2018
Pearls regarding IgG4-RD. Depressed complements commonly seen in renal involvement. #ACR18 @RheumNow pic.twitter.com/m3oM4Aiuny
— Brittany A (@MissbeeMD) October 24, 2018
#IgG4 RD is an indolent disease but can present with severe weight loss (>20 pounds), largely due to pancreatic destruction. #ACR18 @RheumNow
— Brittany A (@MissbeeMD) October 24, 2018
Therapeutic potential of “glycoengineering" in autoimmune disease.
Alter glycoforms of endogenous IgG -> reduce pathogenic impact of antibodies.
Cell paper by Pagan JD et al https://t.co/UbBsE1jV4L
Year in review basic science #ACR18 @RheumNow— D White (@WIRheum) October 21, 2018
TLR8 aberrantly expressed on pDCs (cells that make type-I IFN) in SSc patients
Depletion ameliorates disease https://t.co/SmDdpIU2I1
Ah Kioon et al
Year in review basic science #ACR18 @RheumNow— D White (@WIRheum) October 21, 2018
Stop by the @RheumResearch booth to get your @alhkim autographed flyers!!! #acr18 #rheumrockstars pic.twitter.com/kVR4XB6ynO
— Mary J. Wheatley (@MaryJWheatley) October 22, 2018
Anti-GBM positivity did not predict relapse in Goodpasture's
(but ANCA did predict relapse in GBM disease)
Abs 826, Cleveland Clinic
Roundup – Cush, Kavanaugh
#ACR18 @RheumNow— D White (@WIRheum) October 24, 2018